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While it may be relatively easy to estimate amplifier output noise in cases involving simple amplification or where noise is dominated by flat-band noise, it is fairly complex to do so when the individual noise sources (i.e. thermal, device 1/f, and so on) operate over varied bandwidths and / or where noise is not dominated by the amplifiers flat-band region.
PSpice is a good tool for computing output noise in these cases and it also simplifies what if investigations. This article outlines proper PSpice techniques to simplify the task and shows an example which would be inherently more difficult using other estimation techniques.