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SPICE, the Simulation Program with Integrated Circuits Emphasis, has turned 40 years old. The IEEE has marked the occasion by designating the development of SPICE as a Milestone in Electrical Engineering and Computing. On February 23rd, the Computer History Museum hosted a celebration with a roundtable discussion by the individuals most responsible for bringing SPICE from its origin as a UC Berkeley student project to the huge commercial success it has achieved as the most widely used tool in the semiconductor industry.