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ECG (electrocardiography) is the science of converting the ionic depolarization of the heart to a measurable electrical signal for analysis. One of the most common challenges in the design of analog electronics interfaces to the electrodes or to patients is optimization of the DRL (driven-right-leg) circuit, which is often added to biological-signal amplifiers to reduce common-mode interference and to increase performance and stability. Using Spice to help in this effort can greatly simplify the process.